Phuket City Police were called to the scene, on the southbound lanes near the Premium Outlet mall, at about 1am.
At the scene, officers found the wreckage of a Phuket-registered motorbike that had rear-ended the cement truck and burst into flames.
The rider, named by police only as Atthaphon Boonyuak, 23, originally from Nongkhai, was thrown into the far-right lane and died at the scene.
Witnesses told police that the cement truck had been travelling normally when the motorbike came speeding from behind and struck the rear of the truck with great force.
Restaurant staff nearby attempted to control the fire as the wreckage burned in the middle of the road.
As the blaze was being dealt with, an Isuzu pickup travelling in the middle lane collided with the burning wreckage. Moments later, a black pickup, of unknown make and licence plate, drove through the far-right lane and ran over the victim’s leg before fleeing the scene.
A witness confirmed that both pickup trucks were travelling at high speed when the collisions occurred. The Isuzu pickup remained at the scene, while the black pickup fled without stopping to assist.
Police are now reviewing nearby CCTV footage in a bid to identify the driver of the black pickup and bring them to justice.