A draw at an expectant Anfield would take Arne Slot’s men 13 points clear of Arsenal with just four games remaining, meaning they could not be caught.
Below them, Chelsea and Newcastle have the chance to press their case for Champions League qualification with Manchester City, Nottingham Forest and Aston Villa all involved in the FA Cup semi-finals. At the bottom of the table, Ipswich’s fate could be sealed.
Here we look at three talking points ahead of this weekend’s action:
Liverpool on the brink
It is tough to see struggling Tottenham delaying Liverpool’s title party at Anfield.
After Arsenal’s home draw against Crystal Palace in midweek, Arne Slot’s men just need a draw to seal the deal and pull level with bitter rivals Manchester United on 20 English titles.
Out-of-form Tottenham are 16th in the league table and have a miserable record at Anfield - not winning there since 2011.
Liverpool won the reverse fixture this season 6-3 and were 4-1 winners on aggregate in their two-legged League Cup semi-final.
Captain Virgil van Dijk said it had been an “outstanding season” but that there was still work to do after Liverpool’s 1-0 at Leicester last week.
“Now we have the chance to finish it off on the weekend against a very good Tottenham Hotspur, in my opinion,” he said. “We played three times already against them this season and every game was very intense.
“To be in this position now, it’s a good position but we’re not there yet. We all have to realise that and we will. We’ll make sure of that. It’s a good week of preparation and then we have to be ready.”
Champions League shootout
Just four points separate third-placed Manchester City from Aston Villa in seventh in the race for Champions League spots next season.
For the first time the Premier League’s top five will all qualify for Europe’s top club competition, due to strong performances in continental competition.
Liverpool are already guaranteed a spot and Arsenal, 10 points clear of Chelsea in sixth, are practically there, leaving three places open.
City stole a march this week in the mini-league with a last-gasp win against Villa after Nottingham Forest, now fourth, beat Tottenham on Monday.
Villa play Crystal Palace in the FA Cup semi-finals tomorrow, with Forest taking on City the following day at Wembley.
It means Newcastle, who could have Eddie Howe back on the touchline after a bout of pneumonia, would leapfrog City if they beat lowly Ipswich.
Chelsea badly need to beat Everton at home with a tough run of games to come against Liverpool, Newcastle, Manchester United and Forest.
Southampton playing for pride, Ipswich on brink
Southampton’s 1-1 draw at West Ham last week meant they drew level with Derby’s record-low points tally of 11 from the 2007/08 season, with five games to go to better the Rams’ total.
But it will be of limited comfort after a miserable season for Saints, who were relegated earlier this month.
Leicester are already down and Ipswich appear certain to follow them barring a miracle - a draw for West Ham at Brighton tomorrow would seal their fate.
It would be the second successive season in which all three promoted clubs had been relegated straight back to the Championship.
Prior to the 2023/24 campaign, this had last occurred in 1997/98.
All the evidence points to a worrying and widening chasm between English football’s top two tiers as the season nears its end.
Fixtures (All Phuket times)
Saturday
Chelsea v Everton (6:30pm)
Brighton v West Ham (9pm)
Newcastle v Ipswich (9pm)
Southampton v Fulham (9pm)
Wolves v Leicester (9pm)
Sunday
Bournemouth v Manchester United (8pm)
Liverpool v Tottenham (10:30pm)