The raid, comprising nine officers, including security personnel from the Phuket branch of the Volunteer Defense Force (OrSor), was conducted at about 9:30pm.
The raid followed complaints that there were illegal shops selling kratom juice to teenagers in the area of Tambon Kathu, reported the Phuket office of the Public Relations Department (PR Phuket).
The location of the shop raided and the names of the suspects arrested were not reported.
The two men were taken to Kathu Police Station and charged with selling and distributing a product banned by the Ministry of Public Health, the PR Phuket report confirmed.
The raid in Kathu followed a raid on a shop in Nai Yang on Tuesday where one vendor was caught producing the illegal drink in bulk, with one photo showing more than 100 bottles of kratom juice ready for sale.